ABSTRACT
BACKGROUND: a-n-Butyl cyanoacrylate medical adhesive (504 medical adhesive) has good biocompatibility and anti-bacterial properties. It Is a simple and effective medical adhesive. Little Is reported on the application of a-n-butyl cyanoacrylate medical adhesive in surgical Incision closure In the field of oral cavity. OBJECTIVE: To investigate the effect of a-n-butyl cyanoacrylate medical adhesive on oral mucosal wounds healing. METHODS: Fifteen female SD rat (Laboratory Animal Center of Chongqing Medical University, China) models of oral mucosal Incisions were established and then divided Into a natural healing group (without any treatment), silk suture group (interrupted stitches with absorbable surgical suture), and 504 medical adhesive group (wound closure with a-n-butyl cyanoacrylate medical adhesive) group. At 7 days after surgery, gross and histological observation was performed. Twenty female SD rats were established Into models of 1 cm × 1 cm oral mucosa defect and then divided into two groups: a natural healing group (without any treatment) and a 504 closure group (covering the wound defect with a-n-butyl cyanoacrylate medical adhesive). At 10 days after surgery, gross and histological observation of defect area was performed. This study was approved by the Animal Ethics Committee of Chongqing Medical University, China. RESULTS AND CONCLUSION: Oral mucosal Incision wound model: gross observation showed that the wounds in the three groups healed well, and no inflammatory reaction such as swelling and pus was found. Histological observation showed that the epithelium of the silk suture group was complete and continuous, the nail process of the epithelium was short and flat, the number of fibroblasts in the lamina propria increased, and a large number of inflammatory cells Infiltrated in the suture track area. In the natural healing and 504 closure groups, the mucosal epithelium healed well, the nail process of the epithelium was thin and long, the fibroblasts in the lamina propria proliferated actively, and there were many collagen fibers. The fibers In the 504 closure group were arranged more closely and orderly than those In the silk suture group. Oral mucosa defect model: Gross observation showed that the wound In the natural healing group did not heal completely, and there was no Infection such as swelling, necrosis, and ulceration. In the 504 closure group, wound surface basically healed. Histological observation revealed that In the natural healing group, mucosal defect was obvious, the epithelial layer was not closely connected with the lamina propria, necrotic tissue, a small amount of fibroblasts and a large number of Inflammatory cells were observed. In the 504 closure group, the length of margin of mucosal defect was significantly reduced, fibroblast proliferation and vascular regeneration could be observed in the lamina propria, and fibers were orderly arranged. These results suggest that a-n-butyl cyanoacrylate medical adhesive has little foreign body reaction and can promote the regeneration of mucosal tissue, providing a potential method to close oral mucosal wound.
ABSTRACT
Objective: To compare the application value between medical adhesive and Hook-wire in pre-thoracoscopy localization of small pulmonary nodules (≤ 30 mm). Methods: Data of 107 patients with small pulmonary nodules who underwent thoracoscopic wedge resection, segmental or lobectomy were retrospectively analyzed. The patients were divided into medical adhesive group (88 cases with 90 nodules) and Hook-wire group (19 cases with 19 nodules) according to pre-thoracoscopy localization method. The location of lesion, nodule size, distance between nodule and pleura, nature of nodule(benign or malignant), surgery method and complications (including pneumothorax, pulmonary hemorrhage, pain and cough) were compared between the two groups. Binary Logistic regression analysis was performed to determine the complications' related risk factors. Results: There was no significant difference of the location of lesion, nodules size, distance between nodule and pleura, nature of nodule nor the method of thoracoscopic surgery between the two groups (all P>0.05). The pre-thoracoscopy localization success rate of both two groups were 100%. The overall complication rate and the incidence of pulmonary hemorrhage in medical adhesive group were significantly lower than those in Hook-wire group (both P<0.01). The localization method was an independent risk factor for complications after pre-thoracoscopy localization, pulmonary hemorrhage and chest pain, while the distance from the nodule to pleura was an independent risk factor for pulmonary hemorrhage. Conclusion: Medical adhesive can be used for pre-thoracoscopy localization of small pulmonary nodule with lower complication rate compared with Hook-wire.
ABSTRACT
In recent years, due to the dramatic increase in the number of surgical operations, there has been a clinically significant increase in the demand for medical adhesives capable of cohesion in a moist environment that can overcome blood or tissue fluids . As the understanding of the mechanisms and key elements of natural adhesion to aquatic organisms continues to develop, a variety of medical adhesives have been developed by mimicking adhesion procedures or utilizing key functional groups. This article will review the classification, adhesion mechanism, use, research progress and development prospects of biomedical adhesives inspired by aquatic organisms octopus and mussels.
Subject(s)
Animals , Adhesives , Biomimetic Materials , BivalviaABSTRACT
An 87-year-old woman was referred for the extraction of residual teeth and removal of tori prior to prosthetic treatment. After surgery under general anesthesia, the surgical tape was removed to detach the bispectral index sensor and the hair cover. After the surgical tape was removed, skin injury occurred on the left side of her face. After epidermis repositioning and ointment application, a dressing was placed over the injury. Her wound was found to have healed completely on follow-up examination. Medical adhesive related skin injury (MARSI) is a complication that can occur after surgery and subjects at the extremes of age with fragile skin are at a higher risk for such injuries. Careful assessment of the risk factors associated with MARSI is an absolute necessity.
Subject(s)
Aged, 80 and over , Female , Humans , Adhesives , Anesthesia, General , Bandages , Epidermis , Follow-Up Studies , Hair , Risk Factors , Skin , Surgical Tape , Tooth , Wounds and InjuriesABSTRACT
Objective To analyze prevalence and determinants of medical adhesive-related skin injury (MARSI) in peripherally inserted central catheter implanted patients with lung cancer,to create evidence for improved clinical care.Methods A cross-sectional observational study design was adopted.Skin pictures and electronic medical records of 200 lung cancer patients who visited Shanghai Chest Hospital for PICC between June 2017 and September 2017 were analyzed to calculate prevalence of MARSI and identify related factors.Results The prevalence of MARSI was 31.5％ (63/200),and mechanical trauma accounted for 50.8％ of all cases (32/63).Age,diabetes and anaphylaxis were significantly related to MARSI.Conclusion Analysis of MARSI in PICC implanted patients with lung cancer provided evidence for improved clinical care of such patients.
ABSTRACT
Objective To investigate the current status analysis the risk factors of medical adhesive related skin injury(MARSI) in neonates in NICU, in order to provide guidance in prevention and nursing of the skin injury. Methods Convenience sampling five NICU in Shenyang, prospective investigate the incidence of MARSI of neonates during the NICU stay, and analysis the incidence , injury type distribution and risk factors. Results The incidence of MARSI in neonates in NICU was 12.8%(53/413);the major injury type of MARSI was epidermal stripping(47.2%,25/53)and skin tear(35.8%,19/53) in mechanical injury;Logistic analysis showed that the independent risk factors of MARSI were the use of stomach tube, dehydrate skin and blue light therapy (χ2=5.953, 9.806 and 7.568, P<0.05). Conclusions MARSI is frequency interrupted in neonates during the NICU stay, correct selection of medical adhesive products, application of suitable paste and remove skills are helpful to reduce the incidence of MARSI in neonates during the NICU stay.
ABSTRACT
Objective To assess the validity and safety of arterial embolization with medical adhesive in treating peripheral artery pseudoaneurysms(PSA).Methods 25 cases of peripheral artery PSA embolized with Fuaile medical adhesive(FMA) were analyzed retrospectively.25 patients included 28 PSA.Super-selective transcatheter arterial embolization was performed in 19 patients (22 PSA) using 3F microcatheter and 6 PSA in 6 patients were embolized through puncturing directly.All the lesions were treated with mixtures of FMA and iodized oil (1：1) during the radiography.The clinical efficacy and complications were recorded.Results The success rate of embolization was 100% during the operation (28/28), and the average volume of FMA used was 1.8 mL(0.5-5.5 mL).One patient with PSA(d>2 cm) still have hematuria 2 days after the operation.The hematuria disappeared after embolization with micro-coil following re-angiography.Bleed stopped after the second embolization with FMA in one patient with brachial artery PSA.No one developed complications associated with therapy and occurred rebleeding in the follow-up period time (3 months).Conclusion The mixtures of FMA and iodized oil can be a useful alternative embolic agent for the treatment of peripheral artery pseudoaneurysm with high success rate, short operation time and definite clinical effect.
ABSTRACT
Purpose To evaluate the application value of using a-cyanoacrylate rapid medical glue in preoperative localization of ground-glass nodules under CT guidance.Materials and Methods 48 cases were retrospectively analyzed,in which the pulmonary ground-glass nodules took preoperative localization under CT guidance.The rapid medical glue was injected in pulmonary ground-glass nodules,which was used for preoperative localization.Results After preoperative localization of rapid medical glue in 48 cases,pulmonary ground-glass nodules of all patients were resected successfully by video-assisted thoracoscope surgery (VATS).The complications of pneumothorax did not occur in all cases,with little pulmonary hemorrhagein in 10 cases.Conclusion When the fast medical glue has been used in the CT-guided preoperative localization of ground-glass nodules,there are advantages of high accuracy of localization and surgery.Moreover,this method is simple,safe and effective.
ABSTRACT
Objective To observe the feasibility and security of the embolization with medical adhesive on renal artery in rab‐bits by animal experiments ,and explore the effectiveness of different concentration of embolic agents on the process and the effect of embolization for vascular ,and provide guidance for clinical application of medical adhesive .Methods A mixture of different ratios of lipiodol and medical adhesive were used to embolize the renal artery in 18 rabbits ,the usage and effects of embolization were ob‐served .Results Embolic agents were seen under the fluoroscopy ,easy to control and inject transcatheter ,also repeated injected by one micro‐catheter safety and effectively .Angiography review showed a reliable embolization ,no vascular recanalization and no spill‐over of contrast agent .Optical microscope ,after HE staining in postoperative pathological examination ,showed irregular shaped embolic agents or branch like refractive index of transparent material in the embolized artery .In 5∶1 group and 4∶1 group ,arteri‐ole and small artery were mainly embolized ,there was no significant difference between the two groups(P>0 .05);Whereas medium sized artery was mainly embolized in 3∶1 group ,compared with the 5∶1 group and 4∶1 group ,the differences was statistically significant(P<0 .05) .After operation ,renal function was transient damage ,leukocyte was transient increasing ,one week later ,both of renal function and leukocyte were recovered ,and there was no significantly renal function anomaly .Conclusion It is feasible ,safe and effective for medical adhesive to embolize rabbits renal artery ,the different concentration of the embolic agents can embolize the different branches of rabbit renal artery .
ABSTRACT
Medical adhesive is widely used in the medical care environment,but the medical staff pays little attention to skin injury caused by it.The incidence of medical adhesive-related skin injury is relatively high,and the patients may suffer from pain,infection and so on,result in lowering quality of life.On the basis of literature review,the author reviewed the epidemiology,pathophysiology,types,risk factors,prevention and treatment of the medical adhesive-related skin injury to provide the basis for prevention and care of such skin injury.
ABSTRACT
Objective To investigate and evaluate the clinical effect of the application of medical adhesive in limited septoplasty by endoscope.Methods 57 patients were selected to undergo operation of limited septoplasty by endoscope.The patients were divided into packing group and bonding group.The packing group had 29 patients,whose nasal cavity was packed with vaseline gauze.While the bonding group had 28 patients,their nasal septum mucosa was adhesive fixed by medical adhesive,and the nasal cavity without packing.The indexes included the cardinal symptoms(nasal pain and headach,sleep status),signs (seepage amount of bleeding,mucosal edema),degree of discomfort in nasal cavity processing after operation(pain and bleeding) and length of stay were compared between the two groups.Results The above indexes in the bonding group were apparently lightened than the packing group and the length of stay was shortened.The differences were statistically significant (all P ＜ 0.05).Conclusion In operation of limited septoplasty by endoscope,the using of medical adhesive replacing nasalpacking could reduce the trauma on patients by operation and lighten the pain.The curative effect is satisfactory and it has excellent clinical application value.